Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. Silver is eliminated primarily in the faeces. Metallic silver is oxidized and may deposit in the tissues, causing arygria. Insoluble silver salts are transformed into soluble silver sulfide albuminates, bind to amino or carboxyl groups in RNA, DNA, and proteins, or are reduced to metallic silver by ascorbic acid or catecholamines. It distributes throughout the body in the blood, particularily to the liver. Silver and its compounds can be absorbed via inhalation, while silver compounds can also be absorbed orally and dermally. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Silver nanoparticles are believed to disrupt the mitochondrial respiratory chain, causing oxidative stress, reduced ATP synthesis, and DNA damage. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions and intracellular ion concentrations, respectively. Predicted LC-MS/MS Spectrum - 40V, Positive Predicted LC-MS/MS Spectrum - 20V, Positive Predicted LC-MS/MS Spectrum - 10V, Positive Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive These are inorganic compounds in which the largest oxoanion is nitrate, and in which the heaviest atom not in an oxoanion is a transition metal. Belongs to the class of inorganic compounds known as transition metal nitrates.
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